Association between late-life weight change and dementia: A population-based cohort study.

Jie Guo Anna MarsegliaYing ShangAbigail DoveGiulia GrandeLaura FratiglioniWei-Li Xu

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)

BMI and weight changes showed U-shaped associations with dementia risk. Large body weight gain and loss alike are associated with an almost 3-fold higher risk of dementia, which may be amplified by APOE ɛ4.

Keyphrases

weight gain
mild cognitive impairment
body mass index
birth weight
cognitive impairment
cognitive decline
weight loss
metabolic syndrome
type diabetes
skeletal muscle