The role of interferon-γ in cardiovascular disease: an update.

Ailin ElyasiIryna VoloshynaSaba AhmedLora J KasselmanJennifer BehbodikhahJoshua De LeonAllison Bethanne Reiss

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)

Given the pivotal role of IFN-γ in the advancement of CVD, activation of its signaling pathways is being explored as a driver of atherosclerosis. Manipulation of this key cytokine may lead to novel therapeutic avenues for CVD prevention and treatment. A number of therapies are being explored with IFN-γ as the potential target.

Keyphrases

cardiovascular disease
dendritic cells
immune response
signaling pathway
type diabetes
cardiovascular risk factors
epithelial mesenchymal transition
coronary artery disease
pi k akt
endoplasmic reticulum stress
smoking cessation