Granulocyte colony-stimulating factor has a sex-dependent positive effect in the maternal immune activation-induced autism model.

Ferit Durankuş Yakup Albayrak Fırat Erdoğan Neslihan Albayrak Mümin Alper Erdogan Oytun Erbaş

Published in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2022)

The present research is the first to demonstrate the beneficial effects of G-CSF on core symptoms of ASD experimentally depending on male sex. G-CSF can be a good candidate for ameliorating the core symptoms of ASD without serious side effects in males.

Keyphrases

autism spectrum disorder
intellectual disability
attention deficit hyperactivity disorder
high glucose
diabetic rats
peripheral blood
drug induced
birth weight
pregnancy outcomes
body mass index