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(-)-Epicatechin and Anthocyanins Modulate GLP-1 Metabolism: Evidence from C57BL/6J Mice and GLUTag Cells.

Eleonora CremoniniElena DaveriAngela MastaloudisPatricia I Oteiza
Published in: The Journal of nutrition (2022)
In mice, EC and ACs regulated different steps in GLP-1 regulation, leading to increased plasma GLP-1. Cyanidin, delphinidin, PCA, and EC promoted GLP-1 secretion from GLUTag cells by activating the PKA-dependent pathway. These findings support the beneficial actions of these flavonoids in sustaining intestinal and glucose homeostasis through the modulation of the GLP-1 metabolism.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • signaling pathway
  • endoplasmic reticulum stress
  • cell death
  • transcription factor
  • type diabetes
  • metabolic syndrome
  • skeletal muscle
  • weight loss