Molecular Changes in Chronic Myeloid Leukemia During Tyrosine Kinase Inhibitors Treatment. Focus on Immunological Pathways.
Michał JanowskiZofia UlańczykKarolina ŁuczkowskaAnna SobuśDorota RogińskaEwa Pius-SadowskaMichał GniotKrzysztof KozłowskiKrzysztof LewandowskiGrzegorz HelbigBogusław MachalińskiEdyta PaczkowskaPublished in: OncoTargets and therapy (2022)
Upregulated biological processes according to gene ontology (GO) classification involved basic cellular processes such as cell division, cell cycle, cell-cell adhesion, protein transport, mitotic nuclear division, apoptosis, and DNA replication. Differentially expressed miRNAs were annotated using GO classification to several immunity-related processes, including the T cell receptor signalling pathway, T cell costimulation, immune response, and inflammatory response. TKI therapy exerts a significant impact on cellular cycle processes and T-cell activation, which was proven at the molecular level.
Keyphrases
- cell cycle
- chronic myeloid leukemia
- inflammatory response
- immune response
- cell adhesion
- single cell
- cell proliferation
- machine learning
- deep learning
- cell therapy
- oxidative stress
- endoplasmic reticulum stress
- stem cells
- single molecule
- copy number
- genome wide
- mesenchymal stem cells
- dna methylation
- amino acid
- genome wide analysis
- drug induced