Efficacy of Intravenous Hydroxocobalamin for Treatment of Sodium Methanethiolate Exposure in a Swine Model (Sus scrofa) of Severe Methanethiol Toxicity.

Joseph K MaddryR Madelaine ParedesJennifer RebelesGlen OlsonMaria CastanedaKaysie CanellisPatrick C NgVikhyat S Bebarta

Published in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2020)

In our model of intravenous methanethiolate poisoning, IV HOC administration resulted in a transient improvement in vital signs and prolonged time to death; however, it did not improve survival.

Keyphrases

high dose
oxidative stress
early onset
combination therapy
smoking cessation