Biochanin A impedes STAT3 activation by upregulating p38δ MAPK phosphorylation in IL-6-stimulated macrophages.

Anandita BasuAnindhya Sundar DasPallab Kumar BorahRaj Kumar DuaryRupak Mukhopadhyay

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)

This differential regulation of STAT3 and p38 MAPK in macrophages establishes a novel anti-inflammatory mechanism of BCA which could be important for the prevention of IL-6-associated chronic inflammatory diseases.

Keyphrases

anti inflammatory
cell proliferation
oxidative stress
protein kinase