Role of renin-angiotensin-aldosterone system activation and other metabolic variables in relation to arterial inflammation in HIV.
Grace ShenTeressa S ThomasAllie R WalpertColin M McClureKathleen V FitchChristopher deFilippiMartin TorrianiColleen G BucklessGail K AdlerSteven K GrinspoonSuman SrinivasaPublished in: Clinical endocrinology (2022)
LpPLA2 is increased during a RAAS-activated state among PWH, but not among PWOH. Further, LpPLA2 was increased in both RAAS-activated and suppressed states in PWH compared with PWOH. These data suggest a biological link between increased aldosterone and arterial inflammation in this population. Future studies should test RAAS blockade on arterial inflammation as a targeted treatment approach in HIV.