The central role of a two-way positive feedback pathway in molecular targeted therapies-mediated pyroptosis in anaplastic thyroid cancer.

Qiwu ZhaoHaoran FengZheyu YangJuyong LiangZhijian JinLingxie ChenLing ZhanMing XuanJiqi YanJie KuangXi ChengRen ZhaoWeihua Qiu

Published in: Clinical and translational medicine (2022)

Through pyroptosis mediated by caspase-1-GSDMD and caspase-3-GSDME axes synchronically, low-dosage apatinib and melittin could synergistically achieve a comparable therapeutic potential with reduced AEs. More importantly, a two-way positive feedback interaction is innovatively proposed between these two axes, which provide a new prospect of targeted therapy.

Keyphrases

cell death
nlrp inflammasome
induced apoptosis
oxidative stress
current status
single molecule