CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction.

Qing ZhangLi ChenLiyi HuangHongxin ChengLu WangLin XuDanrong HuChengqi HeChenying FuQuan Wei

Published in: Molecular medicine (Cambridge, Mass.) (2022)

CD44 and its regulated plasma exosomes have crucial potent angiogenic activity. Our studies elucidate that CD44 plays a key role in plasma exosomal miRNA-enhanced angiogenic FGFR2 singling transduction and ischemic angiogenesis in the early stage of myocardial infarction.

Keyphrases

early stage
heart failure
endothelial cells
left ventricular
vascular endothelial growth factor
nk cells
stem cells
mesenchymal stem cells
transcription factor
squamous cell carcinoma
radiation therapy
lymph node
bone marrow