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Hydrogen-Bonded Duplexes with Lengthened Linkers.

Yukun ZhangRuikai CaoJie ShenCadnel S F DetchouYulong ZhongHeng WangSheng ZouQingfei HuangChunxia LianQiwei WangJin ZhuBing Gong
Published in: Organic letters (2018)
Connecting basic hydrogen-bonding units with lengthened flexible or rigid linkers generates oligoamide strands that carry new H-bonding sequences and association specificity, leading to H-bonded homo- and heteroduplexes with association constants in the 104 M-1 range in chloroform. Computational and experimental studies indicate that in duplexes with rigid aromatic linkers the oligoamide strands adopt bent conformations that allow the formation of interstrand H-bonds and accommodate the introduced aromatic liners, offering a new series of association units.
Keyphrases
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