Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.
Thomas KehrerAnastasija CupicChengjin YeSoner YildizMehdi BouhhadouNicholas A CrosslandErika BarrallPhillip CohenAnna TsengTolga ÇağatayRaveen RathnasingheDaniel FloresSonia JangraFahmida AlamNacho MenaSadaf AslamAnjali SaqiArturo MarinMagdalena RutkowskaManisha R UmmadiGiuseppe PisanelliR Blake RichardsonEthan C VeitJacqueline M FabiusMargaret SoucherayBenjamin J PolaccoMatthew J EvansDanielle L SwaneyAna S Gonzalez-ReicheEmilia M SordilloHarm van BakelViviana SimonLorena Zuliani-AlvarezBeatriz M A FontouraBrad R RosenbergNevan J KroganLuis Martinez-SobridoAdolfo García-SastreLisa MiorinPublished in: bioRxiv : the preprint server for biology (2022)
SARS-CoV-2 ORF6 subverts bidirectional nucleo-cytoplasmic trafficking to inhibit host gene expression and contribute to viral pathogenesis.