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Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.

Ahmed Makki A Al-QarakhliNorhayati YusopRachel J WaddingtonRyan Moseley
Published in: BMC molecular and cell biology (2019)
This study demonstrates the limited negative impact of hyperglycaemia on the proliferative and stem cell characteristics of heterogeneous CB-MSC populations, although minor sub-population(s) appear more susceptible to these conditions leading to impaired osteogenic/adipogenic differentiation capabilities. Such findings potentially highlight the impact of hyperglycaemia on CB-MSC bone repair capabilities in situ.
Keyphrases
  • high glucose
  • stem cells
  • bone marrow
  • endothelial cells
  • mesenchymal stem cells
  • oxidative stress
  • bone mineral density
  • body composition
  • bone loss