Direct and transdentinal biostimulatory effects of grape seed extract rich in proanthocyanidin on pulp cells.

A F Dos SantosJ M PachecoP A O SilvaA K Bedran-RussoTaia Maria Berto RezendeP N R PereiraAna Paula Dias Ribeiro

Published in: International endodontic journal (2018)

Treatment with grape seed extract, even at the highest concentration and longest period, caused neither direct nor transdentinal cytotoxic effects on human pulp cells. Grape seed extract components may play a biostimulatory role and protect dental pulp cells when in direct contact.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endothelial cells
endoplasmic reticulum stress
combination therapy