Ancient origin of the rod bipolar cell pathway in the vertebrate retina.

Ayana M HellevikPhilip MardoumJoshua HahnYvonne KölschFlorence D D'OraziSachihiro C SuzukiLeanne GodinhoOwen LawrenceFred RiekeKarthik ShekharJoshua R SanesHerwig BaierTom BadenRachel O WongTakeshi Yoshimatsu

Published in: bioRxiv : the preprint server for biology (2023)

- Zebrafish have two rod bipolar cell types (RBC1/2).- Synaptic connectivity of RBC1 resembles that of the mammalian RBCs.- The primary rod pathway therefore probably evolved more than 400 million years ago.- The second zebrafish RBC type, RBC2, forms a separate pathway from RBC1.

Keyphrases

red blood cell
single cell
cell therapy
bipolar disorder
stem cells
functional connectivity
resting state
white matter