Inhibition of Migration, Invasion and Drug Resistance of Pancreatic Adenocarcinoma Cells - Role of Snail, Slug and Twist and Small Molecule Inhibitors.

Ezgi Kaşıkcı Esra AydemirÖmer Faruk BayrakFikrettin Şahin

Published in: OncoTargets and therapy (2020)

Overall it was found that EMT-ATF silencing, either by EMT-ATF silencing or with the enhancement by small molecules, is a good candidate to treat pancreatic cancer since it simultaneously minimizes metastasis, stem cell properties, and drug resistance.

Keyphrases

epithelial mesenchymal transition
small molecule
induced apoptosis
endoplasmic reticulum stress
stem cells
signaling pathway
transcription factor
cell cycle arrest
protein protein
cell death
pi k akt
oxidative stress
cell proliferation
mesenchymal stem cells
bone marrow
cell therapy