3D in vitro co-culture models based on normal cells and tumor spheroids formed by cyclic RGD-peptide induced cell self-assembly.

Roman A AkasovAnastasia GilevaDaria Zaytseva-ZotovaSergey BurovIsabelle ChevalotEmmanuel GuedonElena Markvicheva

Published in: Biotechnology letters (2016)

The 3D co-culture spheroids are proposed as a tool in tumor biology to study cell-cell interactions as well as for testing novel anticancer drugs and drug delivery vehicles.

Keyphrases

single cell
drug delivery
cell therapy
stem cells
mesenchymal stem cells
cell death
drug release