Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells.
Yajun WuPengyuan LiuWendy ChenShiting BaiSisi ChenJianglin ChenXiaogang XuJindan XiaYufei WuJianjun LaiChuan SunZhenghong LaoXiaoqing WanZhibing WuPublished in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2024)
MW-HT + RT treatment significantly inhibited DNA damage repair by downregulating DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways, leading to increased ROS levels, aggravate DNA damage, apoptosis, and necrosis in PC3 cells, a well-established model of CRPC.
Keyphrases
- dna damage
- dna repair
- oxidative stress
- induced apoptosis
- cell cycle arrest
- dna damage response
- endoplasmic reticulum stress
- pi k akt
- signaling pathway
- cell death
- diabetic rats
- squamous cell carcinoma
- circulating tumor
- single molecule
- cell free
- radical prostatectomy
- locally advanced
- prostate cancer
- combination therapy
- benign prostatic hyperplasia
- reactive oxygen species
- epithelial mesenchymal transition
- cell proliferation
- heat shock protein
- heat shock