Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments.
R J CuthbertE JonesC Sanjurjo-RodríguezAhmed LotfyP GangulyS M ChurchmanP CastanaH B TanD McGonagleEvangelia PapadimitriouP V GiannoudisPublished in: Journal of clinical medicine (2020)
In vitro, non-union site derived MSCs have no impairment of differentiation capacity, but they differ from IP-derived MSCs in mediating angiogenesis. Local MSCs may thus be strongly implicated in the formation of the immature vascular network at the non-union site. Attention should be given to their angiogenic support profile when selecting MSCs for regenerative therapy.