Hematopoietic Stem Cells (HSC) and Granulocyte Macrophage Progenitors (GMP) are the Oxidative Stress Targets in Low/Intermediate-1 Risk Myelodysplastic Syndromes.
Valentina GiaiThea BensiClaudia BertasselloMichela SavioDario FerreroMaria Matilde CirielloMarco LadettoPublished in: Journal of biotechnology and biomedicine (2022)
Our data showed that ROS can play a role in the pathogenesis and maintenance of low and intermediate-1 risk MDS clone; ROS status can be influenced by several clinical factors as ferritin levels and rh-EPO treatment. In this scenario, high ROS levels can contribute to genetic instability and influence progression to AML. Further biological studies are needed to elucidate ROS role in MDS pathogenesis and analyze the possible benefit of antioxidant drugs added to the standard MDS treatments.
Keyphrases
- dna damage
- oxidative stress
- cell death
- reactive oxygen species
- induced apoptosis
- cell cycle arrest
- acute myeloid leukemia
- adipose tissue
- gene expression
- anti inflammatory
- cystic fibrosis
- genome wide
- diabetic rats
- big data
- peripheral blood
- pseudomonas aeruginosa
- copy number
- combination therapy
- artificial intelligence
- case control
- heat shock