Patch-Clamp Recording of Low Frequency Stimulation-induced Long-Term Synaptic Depression in Rat Hippocampus Slices During Early and Late Neurodevelopment.

Cédric BertrandChloé DeschampsKevin RabiantStéphane PeineauJohann AntolMargaret P Martinetti Mickaël NaassilaCatherine VilpouxOlivier Pierrefiche

Published in: Alcoholism, clinical and experimental research (2021)

We concluded that whole-cell patch-clamp recordings are not suitable for studying synaptic LFS-induced LTD in rats older than 4 weeks of age and therefore cannot be used to explore electrophysiological disturbances, such as those induced by alcohol binge drinking during adolescence, which constitutes a late period of brain maturation.

Keyphrases

high glucose
diabetic rats
depressive symptoms
oxidative stress
drug induced
single cell
physical activity
stem cells
endothelial cells
cerebral ischemia
middle aged
mesenchymal stem cells
resting state
brain injury
subarachnoid hemorrhage
functional connectivity