A novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis.
Shejil KumarMatti L GildMichelle M McDonaldAlbert S KimRoderick J Clifton-BlighChristian M GirgisPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2024)
A novel overlapping sequential treatment approach between denosumab and romosozumab produced greater improvements in lumbar spine and hip BMD than previously reported with standard approaches. Larger prospective controlled studies are needed to confirm these findings and establish the optimal use of romosozumab in patients pre-treated with denosumab to maximise BMD gains and minimise fracture risk.