Naringin abrogates angiotensin-converting enzyme (ACE) activity and podocin signaling pathway in cobalt chloride-induced nephrotoxicity and hypertension.
Ademola Adetokunbo OyagbemiTemitayo Olabisi AjibadeOluwaseun Olanrewaju EsanMoses Olusola AdetonaAyobami Deborah ObisesanAdewumi Victoria AdeogunOmolola Victoria AwoyomiJoseph Ayotunde BadejoAduragbenro Deborah A AdedapoTemidayo Olutayo OmobowaleOlayinka Isreal OlaleyeOlufunke Eunice Ola-DaviesAdebowale Benard SabaAdeolu Alex AdedapoSanah Malomile NkadimengLyndy Joy McGawPrudence Ngalula Kayoka-KabongoMomoh Audu YakubuEvaristus NwuliaOluwafemi Omoniyi OguntibejuPublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2022)
Taken together, the antioxidant and metal-chelating action of Naringin administration against cobalt chloride-induced renal damage and hypertension could be through abrogation of angiotensin-converting enzyme and podocin signaling pathway.
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