Insulin Resistance is Associated with Gut Permeability Without the Direct Influence of Obesity in Young Adults.

Lusikelelwe Mkumbuzi Mvuyisi M O Mfengu Godwill Azeh Engwa Constance Rufaro Sewani-Rusike

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)

Insulin resistance was associated with gut permeability without a direct influence by obesity in young adults. The lack of relationship between obesity and insulin resistance was possibly mediated by the contribution of obesity to gut permeability. This finding suggests that gut permeability may be a potential independent risk factor for the development of insulin resistance in healthy obese young adults.

Keyphrases

insulin resistance
young adults
metabolic syndrome
high fat diet induced
adipose tissue
type diabetes
high fat diet
skeletal muscle
polycystic ovary syndrome
weight loss
endothelial cells
glycemic control
risk assessment