Predictive value and accuracy of [ 18 F]FDG PET/CT modified response criteria for checkpoint immunotherapy in patients with advanced melanoma.

Narjess AyatiZahra Jamshidi-AraghiMagdalena HoellwerthGregor Schweighofer-ZwinkWolfgang HitzlPeter KoelblingerChristian PirichMohsen Beheshti

Published in: European journal of nuclear medicine and molecular imaging (2023)

Although the appearance of new lesions can be secondary to an inflammatory response to ICIs and indicative of pseudoprogression, given the higher rate of true progression, the appearance of new lesions should be interpreted deliberately. Of the three assessed modified criteria, PERCIMT appear to provide more reliable metabolic response assessment that correlates strongly with overall patient survival.

Keyphrases

dna damage
case report
cell cycle
oxidative stress
cell proliferation