Cancer-associated fibroblasts show heterogeneous gene expression and induce vascular endothelial growth factor A (VEGFA) in response to environmental stimuli.
Ken-Ichi InoueSatoko KishimotoKazumi AkimotoMasashi SakumaShigeru ToyodaTeruo InoueKen-Ichiro YoshidaMitsugi ShimodaShuji SuzukiPublished in: Annals of gastroenterological surgery (2019)
We have established perturbation-based monitoring of patients' CAF. Further data collection and individual patient follow up is ongoing to identify critical determinants of disease outcome.
Keyphrases
- vascular endothelial growth factor
- gene expression
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- dna methylation
- prognostic factors
- endothelial cells
- machine learning
- extracellular matrix
- climate change
- deep learning
- patient reported
- artificial intelligence
- life cycle