Inflammatory intrathecal profiles and cortical damage in multiple sclerosis.

Roberta MagliozziOwain W HowellRichard NicholasCarolina CrucianiMarco CastellaroChiara RomualdiStefania RossiMarco PitteriMaria Donata BenedettiAlberto GajofattoFrancesca B PizziniStefania MontemezziSarah RasiaRuggero CapraAlessandra BertoldoFrancesco FacchianoSalvatore MonacoRichard ReynoldsMassimiliano Calabrese

Published in: Annals of neurology (2019)

A common pattern of intrathecal (meninges and CSF) inflammatory profile strongly correlates with increased cortical pathology, both at the time of diagnosis and at death. These results suggest a role for detailed CSF analysis combined with MRI as a prognostic marker for more aggressive MS. Ann Neurol 2018 Ann Neurol 2018;83:739-755.

Keyphrases

multiple sclerosis
oxidative stress
neural network
magnetic resonance imaging
mass spectrometry
ms ms
contrast enhanced
cerebrospinal fluid