The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease.
Marita KalaojaLaura J CorbinVanessa Y TanAri V Ahola-OlliAki S HavulinnaKristiina SantalahtiNiina PitkänenTerho LehtimäkiLeo-Pekka LyytikäinenEmma RaitoharjuIlkka SeppäläMika KähönenSamuli RipattiAarno PalotieMarkus PerolaJorma S ViikariSirpa JalkanenMikael MaksimowVeikko SalomaaMarko SalmiOlli T RaitakariJohannes KettunenNicholas John TimpsonPublished in: Obesity (Silver Spring, Md.) (2021)
Observational and MR estimates of the effect of BMI on cytokine levels were generally concordant. There was little evidence for an effect of raised levels of BMI-driven cytokines on disease. These findings illustrate the challenges of MR when applied in the context of molecular mediation.