Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl+ cells.
Sandra Mara BurinMaira da Costa CacemiroJuçara Gastaldi CominalRone Aparecido De GrandisAna Rita Thomazela MachadoFlavia Sacilotto DonairesAdelia Cristina Oliveira CintraLuciana AmbrosioLusânia Maria Greggi AntunesSuely Vilela SampaioFabíola Attié de CastroPublished in: The journal of venomous animals and toxins including tropical diseases (2020)
BmooLAAO-I exerts selective antitumor action mediated by H2O2 release and induces apoptosis, and alterations in epigenetic mechanisms. These results support future investigations on the effect of BmooLAAO-I on in vivo models to determine its potential in CML therapy.