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Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.

Maria J FortezaMartin BergAndreas EdsfeldtJangming SunRoland BaumgartnerIlona KareinenFelipe Beccaria CasagrandeUlf HedinSong ZhangIvan VuckovicPetras P DzejaKonstantinos A PolyzosAnton GisteråMette TrauelsenThue W SchwartzLea DibJoerg HerrmannClaudia MonacoLjubica MaticIsabel GonçalvesDaniel Francisco Jacon Ketelhuth
Published in: Cardiovascular research (2023)
We have demonstrated for the first time that the PDK/PDH axis is associated with vascular inflammation in humans, and particularly that the PDK1 isozyme is associated with more severe disease and could predict secondary cardiovascular events. Moreover, we demonstrate that targeting the PDK/PDH axis with DCA skews the immune system, inhibits vascular inflammation and atherogenesis, and promotes plaque stability features in Apoe-/- mice. These results point toward a promising treatment to combat atherosclerosis.
Keyphrases
  • cardiovascular events
  • oxidative stress
  • cardiovascular disease
  • coronary artery disease
  • high fat diet
  • type diabetes
  • tyrosine kinase
  • adipose tissue
  • smoking cessation