RB1CC1 duplication and aberrant overexpression in a patient with schizophrenia: further phenotype delineation and proposal of a pathogenetic mechanism.

Edoardo Errichiello Roberto Giorda Antonella Gambale Achille Iolascon Orsetta Zuffardi Sabrina Rita Giglio

Published in: Molecular genetics & genomic medicine (2020)

We hypothesized a pathogenetic model that might explain the correlation between RB1CC1 overexpression and schizophrenia by altering different cell signaling pathways, including autophagy, a promising therapeutic target for schizophrenic patients.

Keyphrases

pi k akt
signaling pathway
cell proliferation
bipolar disorder
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
single cell
peritoneal dialysis
prognostic factors
endoplasmic reticulum stress