Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation.

Jerry XuArianna Harris-KawanoJacob R EnriquezRaghavendra G Mirmira Emily K Sims

Published in: bioRxiv : the preprint server for biology (2024)

Our findings highlight nSMase2 as a regulator of β cell EV cargo and identify ceramide-enriched EV populations as a contributor to EV-related paracrine signaling under conditions of β cell inflammatory stress.

Keyphrases

single cell
cell therapy
transcription factor
mesenchymal stem cells
stress induced