Nanoscale metal-organic frameworks for tumor phototherapy.
Xuan HuangXu SunWeili WangQing ShenQian ShenXuna TangJinjun ShaoPublished in: Journal of materials chemistry. B (2021)
Metal-Organic Frameworks (MOFs) are constructed from metal ions/cluster nodes and functional organic ligands through coordination bonds. Owing to the advantages of diverse synthetic methods, easy modification after synthesis, large adsorption capacity for heavy metals, and short equilibrium time, considerable attention has recently been paid to MOFs for tumor phototherapy. Through rational tuning of metal ions and ligands, MOFs present abundant properties for various applications. Light-triggered phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is an emerging cancer treatment approach. Nanosized MOFs can be applied as phototherapeutic agents to accomplish phototherapy with excellent phototherapeutic efficacy. This review outlines the latest advances in the field of phototherapy with various metal ion-based MOFs.
Keyphrases
- metal organic framework
- photodynamic therapy
- heavy metals
- aqueous solution
- quantum dots
- risk assessment
- water soluble
- squamous cell carcinoma
- fluorescence imaging
- radiation therapy
- mass spectrometry
- high resolution
- atomic force microscopy
- lymph node
- molecular dynamics simulations
- health risk assessment
- rectal cancer
- drinking water
- neoadjuvant chemotherapy
- locally advanced