Urodynamic effects of intravenous and intrathecal administration of E-series prostaglandin 1 receptor antagonist on detrusor overactivity in rats with spinal cord injury.

Naoki WadaKatsumi KadekawaTsuyoshi MajimaTakahiro ShimizuPradeep TyagiHidehiro KakizakiNaoki Yoshimura

Published in: Neurourology and urodynamics (2017)

The PGE2-induced activation of EP1 receptors in the spinal cord contributes to the initiation of detrusor overactivity in SCI. Thus, the EP1 receptor could be a therapeutic target for the treatment of neurogenic detrusor overactivity due to SCI.

Keyphrases

botulinum toxin
spinal cord injury
spinal cord
neuropathic pain
high glucose
diabetic rats
oxidative stress
low dose
drug induced
lower urinary tract symptoms
combination therapy
urinary incontinence
smoking cessation