Transient epidermal barrier deficiency and lowered allergic threshold in filaggrin-hornerin (FlgHrnr-/- ) double-deficient mice.

Sebastian RahrigJudith M DettmannBirka BraunsVerena N LorenzTimo BuhlSanja KezicPeter M EliasStephan WeidingerMartin MempelMichael P SchönAndrea Braun

Published in: Allergy (2019)

Together, our FlgHrnr-/- mouse model nicely reflects the epicutaneous sensitization susceptibilities and inflammatory reactions to environmental insults in humans with impaired skin barrier functions.

Keyphrases

mouse model
wound healing
atopic dermatitis
oxidative stress
soft tissue
cerebral ischemia
human health
allergic rhinitis
life cycle
smoking cessation