Perivascular macrophages create an intravascular niche for CD8+ T cell localisation prior to the onset of fatal experimental cerebral malaria.
Jim QinMichael D LovelaceAndrew J MitchellTania de Koning-WardGeorges Er GrauSaparna PaiPublished in: Clinical & translational immunology (2021)
Our study suggests an active interaction between PVM and CD8+ T cells occurs across the blood-brain barrier (BBB) in early ECM, which may be the initiating event in the inflammatory cascade leading to BBB alteration and neuropathology.