Nipple Localization in Automated Whole Breast Ultrasound Coronal Scans Using Ensemble Learning.

Nipple is a vital landmark in the breast lesion diagnosis. Although there are advanced computer-aided detection (CADe) systems for nipple detection in breast mediolateral oblique (MLO) views of mammogram images, few academic works address the coronal views of breast ultrasound (BUS) images. This paper addresses a novel CADe system to locate the Nipple Shadow Area (NSA) in ultrasound images. Here the Hu Moments and Gray-level Co-occurrence Matrix (GLCM) were calculated through an iterative sliding window for the extraction of shape and texture features. These features are then concatenated and fed into an Artificial Neural Network (ANN) to obtain probable NSA's. Later, contour features, such as shape complexity through fractal dimension, edge distance from the periphery and contour area, were computed and passed into a Support Vector Machine (SVM) to identify the accurate NSA in each case. The coronal plane BUS dataset is built upon our own, which consists of 64 images from 13 patients. The test results show that the proposed CADe system achieves 91.99% accuracy, 97.55% specificity, 82.46% sensitivity and 88% F-score on our dataset.