A Multifield Study on Dimethyl Acetylenedicarboxylate: A Reagent Able to Build a New Cycle on Diaminoimidazoles.

Dmitrii Yu Vandyshev Oleg N BurovAnton V LisovinDaria A MangushevaMikhail A Potapov Tatiana N IlyinovaKhidmet S ShikhalievGeronikaki AthinaDomenico Spinelli

Published in: Molecules (Basel, Switzerland) (2022)

A new effective method for the synthesis of imidazo[1,5- b ]pyridazines derivatives (yields = 68-89%) by the interaction of 1,2-diamino-4-phenylimidazole with DMAD, in methanol and in the presence of a catalytic amount of acetic acid, is proposed. The course of reaction has been examined by classical organic methods, HPLC-MS analysis, and quantum-chemical calculations.

Keyphrases

ms ms
molecular dynamics
mass spectrometry
multiple sclerosis
simultaneous determination
density functional theory
molecular dynamics simulations
high performance liquid chromatography
carbon dioxide
liquid chromatography
water soluble
structure activity relationship