mtDNA depletion-like syndrome in Wilson disease.

Valentina MediciGaurav V SarodeEleonora NapoliGyu-Young SongNoreene M ShibataAndre O GuimarãesCharles E MordauntDorothy A KiefferTagreed A MaziAnna CzlonkowskaTomasz LitwinJanine M LaSalleCecilia Giulivi

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

This study underlines the relevance of targeting the copper-mitochondrial DNA pool in the treatment of WD separate from the established copper-induced oxidative stress-mediated damage.

Keyphrases

mitochondrial dna
copy number
oxidative stress
hydrogen peroxide
dna methylation
cancer therapy
case report
nitric oxide