Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer.

Yun ZhouWenyao ZhangBoda WangPei WangDanxiu LiTianyu CaoDawei ZhangHua HanMingfeng BaiXin WangXiaodi ZhaoYuanyuan Lu

Published in: Journal for immunotherapy of cancer (2024)

Our work provides clear a understanding of immunogenic cell death triggered by mitochondria-targeted PDT, offering a new approach for enhancing the efficacy of PD-1 blockade in CRC.

Keyphrases

cell death
photodynamic therapy
cancer therapy
fluorescence imaging
reactive oxygen species
nlrp inflammasome
drug delivery
induced apoptosis