H4K20me3 co-localizes with activating histone modifications at transcriptionally dynamic regions in embryonic stem cells.

Published in: BMC genomics (2018)

Overall, these findings highlight a previously undescribed subnetwork of ES cell transcriptional circuitry that utilizes dual marking of the repressive H4K20me3 mark with activating histone modifications.

Keyphrases

embryonic stem cells
signaling pathway
dna methylation
single cell
gene expression
cell therapy
transcription factor
heat shock
mesenchymal stem cells