Identification of Distinct Clinical Phenotypes of Heterogeneous Mechanically Ventilated ICU Patients Using Cluster Analysis.
Xuanhui ChenJiaxin LiGuangjian LiuXiujuan ChenShuai HuangHuixian LiSiyi LiuDantong LiHuan YangHaiqing ZhengLianting HuLingcong KongHuazhang LiuAbdelouahab BellouLiming LeiHuiying LiangPublished in: Journal of clinical medicine (2023)
This retrospective study aimed to derive the clinical phenotypes of ventilated ICU patients to predict the outcomes on the first day of ventilation. Clinical phenotypes were derived from the eICU Collaborative Research Database (eICU) cohort via cluster analysis and were validated in the Medical Information Mart for Intensive Care (MIMIC-IV) cohort. Four clinical phenotypes were identified and compared in the eICU cohort (n = 15,256). Phenotype A (n = 3112) was associated with respiratory disease, had the lowest 28-day mortality (16%), and had a high extubation success rate (~80%). Phenotype B (n = 3335) was correlated with cardiovascular disease, had the second-highest 28-day mortality (28%), and had the lowest extubation success rate (69%). Phenotype C (n = 3868) was correlated with renal dysfunction, had the highest 28-day mortality (28%), and had the second-lowest extubation success rate (74%). Phenotype D (n = 4941) was associated with neurological and traumatic diseases, had the second-lowest 28-day mortality (22%), and had the highest extubation success rate (>80%). These findings were validated in the validation cohort (n = 10,813). Additionally, these phenotypes responded differently to ventilation strategies in terms of duration of treatment, but had no difference in mortality. The four clinical phenotypes unveiled the heterogeneity of ICU patients and helped to predict the 28-day mortality and the extubation success rate.
Keyphrases
- mechanical ventilation
- end stage renal disease
- cardiovascular disease
- intensive care unit
- cardiovascular events
- ejection fraction
- newly diagnosed
- cardiac surgery
- chronic kidney disease
- peritoneal dialysis
- risk factors
- type diabetes
- spinal cord injury
- respiratory failure
- emergency department
- quality improvement
- extracorporeal membrane oxygenation
- insulin resistance
- brain injury
- smoking cessation
- cardiovascular risk factors
- electronic health record
- adverse drug