Systemic Immune Inflammation Index: A Novel Predictor of Contrast-Induced Nephropathy in Patients With Non-ST Segment Elevation Myocardial Infarction.
Saban KelesogluYucel YilmazDeniz ElçikZeki ÇetınkayaMehmet Tugrul InancAli DoganAbdurrahman OguzhanNihat KalayPublished in: Angiology (2021)
We investigated whether the systemic immune inflammation index (SII) on admission is an independent risk factor that predicts the development of contrast-induced nephropathy (CIN) in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent percutaneous coronary intervention (PCI). A total of 429 patients with NSTEMI were enrolled in the study. Contrast-induced nephropathy was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 hour after the procedure. Patients were divided into 2 groups: with and without CIN. Demographics, clinical risk factors, angiographic and laboratory parameters, CIN incidence, and SII score were compared between the 2 groups. Non-ST segment elevation myocardial infarction patients, who developed CIN, had higher glucose levels (P = .009), neutrophil counts (P < .001), platelet counts (P < .001), neutrophil-lymphocyte ratios (P < .001), high sensitivity C-reactive protein levels (P = .009), and SII levels (P < .001) than those who did not develop CIN. The receiver operating characteristic curve analysis showed that at a cutoff of 933.2, the value of SII exhibited 77.6% sensitivity and 69.2% specificity for detecting CIN. Our study showed that the SII levels on admission were independently associated with CIN development after PCI in patients with NSTEMI.
Keyphrases
- st segment elevation myocardial infarction
- percutaneous coronary intervention
- risk factors
- acute myocardial infarction
- st elevation myocardial infarction
- acute coronary syndrome
- coronary artery disease
- antiplatelet therapy
- coronary artery bypass grafting
- diabetic rats
- oxidative stress
- high glucose
- magnetic resonance
- emergency department
- drug induced
- atrial fibrillation
- end stage renal disease
- peripheral blood
- type diabetes
- metabolic syndrome
- endothelial cells
- coronary artery bypass
- chronic kidney disease
- magnetic resonance imaging
- prognostic factors
- minimally invasive
- heart failure
- single molecule
- blood glucose
- patient reported outcomes
- atomic force microscopy