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An integrative analysis of genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA detects noninvasive diagnostic markers for gliomas.

Jiajun CaiChang ZengWei HuaZengxin QiYanqun SongXingyu LuDongdong LiZhou ZhangXiaolong CuiXin ZhangZixiao YangJinsen ZhangKai QuanWei ZhuJiabin CaiChuan HeShi-Yuan ChengWei ZhangYing Mao
Published in: Neuro-oncology advances (2021)
The 5hmC-Seal in cfDNA offers the promise as a noninvasive approach for effective detection of gliomas in a screening program.
Keyphrases
  • high grade
  • genome wide
  • dna methylation
  • quality improvement
  • loop mediated isothermal amplification
  • big data
  • label free
  • real time pcr
  • copy number
  • gene expression
  • machine learning
  • artificial intelligence