PD1hi cells associate with clusters of proliferating B-cells in marginal zone lymphoma.

Katherine WickendenNadia NawazSami MamandDeevia KotechaAmy L WilsonSimon D WagnerMatthew J Ahearne

Published in: Diagnostic pathology (2018)

The unexpected architectural complexity of T-cell infiltration in marginal zone lymphoma, revealed in this study, further supports a key role for Tfh cells in driving proliferation of lymphoma B-cells. We demonstrate the feasibility of digital analysis of spatial architecture of T-cells within marginal zone lymphoma and future studies will be needed to determine the clinical importance of these observations.

Keyphrases

diffuse large b cell lymphoma
induced apoptosis
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
cell death
cell proliferation
pi k akt
case control