Effects of the Acute and Chronic Ethanol Intoxication on Acetate Metabolism and Kinetics in the Rat Brain.

Ya-Ju HsiehLiang-Chih WuChien-Chih KeChi-Wei ChangJung-Wen KuoWen-Sheng HuangFu-Du ChenBang-Hung YangHsiao-Ting TaiSharon Chia-Ju ChenRen-Shyan Liu

Published in: Alcoholism, clinical and experimental research (2018)

In vivo PET study confirmed the modulatory role of EtOH, administered acutely or chronically, in [1-11 C]-acetate kinetics and metabolism in the rat brain. Acute EtOH intoxication may inhibit the transport and metabolism of acetate in the brain, whereas chronic EtOH exposure may lead to the adaptation of the rat brain to EtOH in acetate utilization. [1-11 C]-acetate PET imaging is a feasible approach to study the effect of EtOH on acetate metabolism in rat brain.

Keyphrases

pet imaging
liver failure
drug induced
respiratory failure
multiple sclerosis
aortic dissection
brain injury