Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride.

Jeroen B I SapThomas C WilsonChoon Wee Kee Natan J W StraathofChristopher W Am EndeParamita MukherjeeLei ZhangChristophe GenicotVéronique Gouverneur

Published in: Chemical science (2019)

Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation.

Keyphrases

drinking water
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transition metal
computed tomography