Biochemical and inflammatory modifications after switching to dual antiretroviral therapy in HIV-infected patients in Italy: a multicenter retrospective cohort study from 2007 to 2015.
Eugenia Quiros-RoldanPaola MagroElena RaffettiIlaria IzzoAlessandro BorghettiFrancesca LombardiAnnalisa SaracinoFranco MaggioloFrancesco Castellinull nullPublished in: BMC infectious diseases (2018)
Increased PLR has been linked to hypercholesterolemia and metabolic-syndrome, while high CD8+ cells count to increased risk of non-AIDS-related events regardless of CD4 T-cell recovery and to virological failure. Whether these findings may have clinical implications, and which role DT plays on the immune system and on inflammation should be further investigated.
Keyphrases
- antiretroviral therapy
- hiv infected patients
- hiv infected
- human immunodeficiency virus
- metabolic syndrome
- hiv positive
- oxidative stress
- hiv aids
- induced apoptosis
- cell cycle arrest
- insulin resistance
- endoplasmic reticulum stress
- uric acid
- cell death
- clinical trial
- signaling pathway
- cardiovascular disease
- cardiovascular risk factors
- hepatitis c virus
- south africa
- coronary artery disease
- pi k akt