The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: a bioinformatics study.

The shared genetic variations (i.e., rs16944 on the IL-1β gene and ε4 variation of APOE gene) may explain the underlying pathomechanisms of the comorbidity between three common SADs (i.e., IDDM, SLE, and RA) and TLE. Exploring such shared genetic variations may help find targeted therapies for patients with TLE, especially those with drug-resistant seizures who also have comorbid SADs.