A Silver Compound with Potential Applications as an Anticancer, Antibacterial, Antifungal, and Anti-Alzheimer's Agent.
Nesrin KorkmazDursun KısaÖzlem KaplanNazan Gökşen TosunAykut ÖzgürRizvan ImamoğluAhmet KaradağPublished in: Chemistry & biodiversity (2023)
This study investigated the biological activity of the silver coordination compound K-22. The IC 50 values of K-22 on cancer cell lines range from 0.797 μg/mL to 3.426 μg/mL, indicating that K-22 might preferably inhibit A549, Saos-2, MCF-7, and HT-29 cell proliferation and thus have better therapeutic activity. Furthermore, K-22 stimulated apoptosis via up-regulation of the mRNA and protein expression level of Bax/Bcl-2 ratio in A549, Saos-2, MCF-7, and HT-29. K-22 exhibited antimicrobial activity against S. aureus, E. faecalis, K. pneumonia, P. aeruginosa, C. utilis, and C. albicans. Experimental results show that the compound has inhibitory potential with an IC 50 value of 178.10 μM for the BChE (butyrylcholinesterase) enzyme, which has a vital role in the progression of Alzheimer's disease. As a result, compound K-22 exhibits a strong potential for medical use due to its anticancer, antibacterial, antifungal, and anti-Alzheimer properties.
Keyphrases
- candida albicans
- silver nanoparticles
- cell proliferation
- cognitive decline
- breast cancer cells
- oxidative stress
- human health
- squamous cell carcinoma
- cell death
- cell cycle
- mass spectrometry
- intensive care unit
- cell cycle arrest
- signaling pathway
- climate change
- extracorporeal membrane oxygenation
- young adults
- high resolution
- childhood cancer